Emulsions Containing 9,1O-Dimethyl-1, 2-Benzanthracene
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چکیده
Emulsions of fat suitable for intravenous ad ministration have been used in this laboratory as @ source of calories, as an aid in the study of lipid metabolism, and as a vehicle for fat-soluble ma tenials. The latter use has been of value in studies with rats on the effects of the intravenous injection Cof carcinogenic hydrocarbons. Several investiga tions have been reported in which emulsions or suspensions of carcinogenic compounds have been given intravenously to experimental animals. Andervont and Lorenz (1) reported that mice of the C3H strain developed pulmonary tumors fol lowing the intravenous injection of suspensions of I ,@,5,6-dibenzanthnacene. Shimkin (6) reported that strain A mice developed pulmonary tumors after intravenous injection of @0-methylcholan threne in an emulsion. No neoplasms were found by Garay and Berencsi (3) to develop in mice or rabbits after the intravenous administration of suspended S,4-benzpyrene. The rapid excretion of intravenously administered radioactive dibenzan thracene has been reported by Heidelberger and
منابع مشابه
Dimethyl sulfoxide, a convenient solvent of 7,12-dimethylbenz(a)anthracene for intravenous injection.
SUMMARY Dimethyl sulfoxide is a convenient solvent of 7,12-dimethylbenz(a)anthracene and related polycycic aromatic hydrocarbons for i.v. injection. As judged by its ability to induce both adrenal necrosis and mammary tumors, this solu tion is at least as active as fatty emulsions of 7,12-dimethyl benz(a)anthracene now in general use. While the preparation of emulsions is timeconsuming andrequi...
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Studies in Cucinogenesis. V. Methyl Derivatives of 1 : 2-Benzanthracene, M. J. SHEAR. In a further contribution to his series of studies on carcinogenesis Shear records his experiments with the methyl derivatives of 1 : 2-benzanthracene and related compounds. Of 21 compounds examined 10 produced tumors in mice a t the injection site. The more potent carcinogenic compounds were 5 : 10-dimethyl-1...
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Intravenously administered oil emulsions which contain 9,10-dimethyl-l,2-benzanthracene have been shown previously to produce a fairly high in cidence of mammary tumors in female rats (5). Male rats, however, developed few tumors, and these were chiefly papillomas arising from the se baceous gland ducts of external ears. During these and subsequent studies it became apparent that tumor incidenc...
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